Find out about the latest opportunities to join the SInFoNiA team
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SInFoNiA is a vibrant, dynamic and collaborative environment to support your fellowship. We have a wide variety of experienced and early career researchers engaged in diverse aspects of nucleic acid biology and spanning across Science, Engineering and Medical faculties.
Our researchers are highly collaborative, and interactions are supported at our monthly Research Discussions Seminar series.
If you are interested in hosting your fellowship at SInFoNiA, please contact our director Stuart Wilson.
We have a wide variety of PhD positions available across the Institute. If you are interested in doing a PhD with us, please contact the host group directly.
BBSRC White Rose DTP studentships
MRC DiMeN DTP studentships
4 year MRC studentship, under the MRC DiMeN Doctoral Training Partnership.
Studentships are available to UK and EU students who meet the UK residency requirements. Further information on eligibility’s available here.
HOW DO NON-CODING ENHANCER RNAS CONFER GENETIC RISK IN AMYOTROPHIC LATERAL SCLEROSIS (ALS)?
Amyotrophic Lateral Sclerosis (ALS) is an aggressive neurodegenerative disease with no effective therapy. The established genetic causes of ALS can only explain a small fraction of the observed disease phenotypes. This project will explore how newly uncovered disease mutations in non-coding regions of the genome contribute to ALS. Large scale whole genome sequencing (WGS) in ALS patients has highlighted the importance of new mutations in non-coding enhancers. Enhancers are gene regulatory elements crucial for cell-lineage specific gene expression, and are transcribed into non-coding RNAs called enhancer RNAs (eRNAs). You will lead a project to investigate whether novel non-coding ALS mutations affect the structure of eRNAs, and whether this affects epigenetic chromatin modifications and gene expression to drive ALS disease progression.
The project will establish a new and exciting collaboration between two Wellcome Trust Funded groups at the University of Sheffield. The Bose Lab is at the forefront of efforts to uncover the molecular basis for eRNA function. The Cooper-Knock lab leads analysis of the non-coding genome for WGS consortium Project MinE (www.projectmine.com), enabling identification and analysis of rare genetic associations in ALS. The project therefore provides a unique opportunity to work in some of the newest and fastest moving fields in science: molecular mechanisms of non-coding RNAs and the contribution of non-coding disease mutations to complex diseases.
You will receive a broad, multidisciplinary training in functional genomics approaches. This will include techniques for both high-throughout (in-cell) and targeted (in vitro) determination of RNA structure; next-generation and Nanopore sequencing (ChIPseq, NETseq and long-read RNAseq); targeted genome and epigenome editing (CRISPR/CRISPRa/i). Importantly, the project offers a unique opportunity to link these experimental approaches at the bench to bioinformatics training, including development of new deep-learning models for predicting genetic variants in ALS. The work will provide a new understanding of one of the most relevant questions in biology, with broad implications for disease mechanisms in common human diseases.
You will be supervised by Dr Daniel Bose (Dept. of Molecular Biology and Biotechnology) and Dr Johnathan Cooper-Knock (Dept. of Neuroscience). You will join our collaborative, supportive and tight-knit research groups and wider communities with the SInFoNiA and SITraN research centres. You will also join an active, friendly and lively PhD student cohort at the University of Sheffield, which hosts regular social events alongside networking and career development opportunities. We are committed to supporting the career development of our students and encourage attendance at both International and UK meetings, conferences and training courses to develop your research skills and interests.