Sheffield Institute for Nucleic Acids

Professor Mark Dickman

Research Interests

Professor Dickman’s research focuses on the development and application of analytical techniques to study biological systems. He and his group have developed and utilised a range of analytical methods for the analysis of nucleic acids. In particular, the group have developed ion pair reverse phase HPLC in conjunction with mass spectrometry to analyse nucleic acids, including oligonucleotide therapeutics and biological RNA.

Biological mass spectrometry in conjunction with bioseparations have been utilised to study a wide variety of biological systems. Using these analytical approaches we are interested in identifying and characterising protein complexes, protein-RNA/DNA complexes, protein post translational modifications and RNA post transcriptional modifications.

  • Biological mass spectrometry
  • Nucleic acid separations
  • Post-translational and post-transcriptional modifications
  • Nucleic acid/protein interactions
  • CRISPR systems

Publications

  • A Burkholderia pseudomallei toxin inhibits helicase activity of translation factor eIF4A. Cruz-Migoni A, Hautbergue GM, Artymiuk PJ, Baker PJ, Bokori-Brown M, Chang CT, Dickman MJ, Essex-Lopresti A, Harding SV, Mahadi NM, Marshall LE, Mobbs GW, Mohamed R, Nathan S, Ngugi SA, Ong C, Ooi WF, Partridge LJ, Phillips HL, Raih MF, Ruzheinikov S, Sarkar-Tyson M, Sedelnikova SE, Smither SJ, Tan P, Titball RW, Wilson SA, Rice DW. Science, 2011, 334 (6057) 821-824
Professor Mark Dickman
Professor of Bioanalytical Science and Engineering
Department of Chemical and Biological Engineering
+44 (0)114 222 7541
m.dickman@sheffield.ac.uk