Sheffield Institute for Nucleic Acids

Professor Alastair Goldman

Research Interests

Over the years Professor Goldman’s laboratory has worked on a wide range of issues effecting DNA repair and chromosome segregation during meiosis.  These include analysis of repair intermediates at a site-specific DNA double-strand break caused by the meiosis specific VMA1 derived endonuclease.

Current projects are centred on the cohesion protein Scc3 and aspects of its function in meiosis and mitotis, in collaboration with Dr Bin Hu.  The group are also analysing the importance of a helicase in meiosis, to determine how it influences DNA repair and chromosome segregation.  Among the centre collaborations, Professor Goldman works closely with Helen Bryant to analyse the levels and significance of, so called, test cancer antigen gene expression in cancer cells or tumour samples.  The aim of this work is to discover new cancer biomarkers, and possibly new targets for treatment.  Professor Goldman also has joint studentships with Professor Sherif El-Khamisy to address repair of different types of damage in human cells.


Publications

  • Penedos A., Johnson A.L., Strong E, Goldman A.S.H., Carballo J.A., and Cha R.S. (2015) Essential and Checkpoint functions of budding yeast ATM and ATR during meiotic prophase are facilitated by differential phosphorylation of a meiotic adaptor protein, Hop1. PLoS One 30;10(7):e0134297
  • Lafta IJ., Bryant HE. and Goldman A.S.H. (2014). ‘Sex’ in the cancer cell. Oncotarget 30:7984-5.
  • Gray S., Allison R.M., Garcia V., Goldman A.S.H., Neale M.J. (2013) Positive regulation of meiotic DNA double-strand break formation by activation of the DNA damage checkpoint kinase Mec1(ATR). Open Biol., 7:130019.
  • Penfold, C., Brown, P.E., Lawrence, N. and Goldman, A.S.H. (2012) Modelling Meiotic Chromosomes Indicates a Size Dependent Contribution of Telomere Clustering and Chromosome Rigidity to Homologue Juxtaposition. PLoS Comput. Biol. 8:e1002496.
  • Keelagher, R.E., Cotton, V.E., Goldman, A.S.H. and Borts, R.H. (2011) Separable roles for Exonuclease I in meiotic DNA double-strand break repair. DNA Repair (Amst), 10:126-137.
  • Hodgson, A., Terentyev, Y., Johnson, R.A., Bishop-Bailey, A., Angevin, T., Croucher, A. and Goldman, A.S.H. (2011) Mre11 and Exo1 contribute to the initiation and processivity of resection at meiotic double-strand breaks made independently of Spo11. DNA Repair (Amst), 10:138-148.
  • Terentyev, Y., Johnson, R., Neale, M.J., Khisroon, M., Bishop-Bailey, A. and Goldman, A.S.H. (2010) Evidence that MEK1 positively promotes interhomologue double-strand break repair. Nucleic Acids Res, 38:4349-4360.
  • Blundred, R., Myers, K., Helleday, T., Goldman, A.S.H. and Bryant, H.E. (2010) Human RECQL5 overcomes thymidine-induced replication stress. DNA Repair (Amst), 9:964-975.
Professor Alastair Goldman
Professor of Fungal Genetics, Centre Coordinator Biomedical Life Science Interface
Department of Molecular Biology and Biotechnology
+44 (0) 114 222 2779
a.goldman@sheffield.ac.uk