Sheffield Institute for Nucleic Acids
Dr Emma Thomson
Dr Thomson has worked in the field of ribosome biogenesis and RNA processing for almost 15 years. Ribosome biogenesis is a fundamental cellular process that is inextricably linked to cell growth and proliferation. Uncontrolled cell growth is associated with increased levels of ribosome biogenesis and almost 40% of ribosome biogenesis factors identified in human cells have been implicated in cancer. Further, it is emerging that the site of ribosome assembly, the nucleolus, acts as a key stress sensor, where many cellular stresses converge and act to trigger p53 stabilisation resulting in growth arrest, apoptosis or cellular senecescence. The focus of the lab is to dissect the molecular mechanisms linking and regulating these processes through the analysis of the conserved protein GLTSCR2, one of the few factors that is directly involved in each of these pathways.
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- Manikas RG*, Thomson E*, Thoms M, Hurt E. (2016) The K⁺-dependent GTPase Nug1 is implicated in the association of the helicase Dbp10 to the immature peptidyl transferase centre during ribosome maturation. Nuc Acid Res. 44:1800-12 * joint first authors.
- Thoms M*, Thomson E*, Baßler J, Gnädig M, Griesel S, Hurt E. (2015) The Exosome is Recruited to RNA substrates Through Specific Adaptor Proteins. Cell 162:1029-38 * joint first authors.
- Thomson E, Ferreira-Cerca S, Hurt E. (2013) Eukaryotic ribosome biogenesis at a glance. J Cell Sci. 126:4815-21
- Stelter P, Kunze R, Radwan M, Thomson E, Thierbach K, Thoms M, Hurt E. (2012) Monitoring spatiotemporal biogenesis of macromolecular assemblies by pulse-chase epitope labeling Mol Cell 47:788-96