Sheffield Institute for Nucleic Acids

Dr Chris Toseland

Research interests

The mammalian nucleus is a complex, highly organised but dynamic environment. The Toseland lab is interested in the organisation of this environment with respect to transcription and DNA repair. From a medical perspective, we investigate how these processes are manipulated by cancer cells so that we may be able to identify therapeutic targets.

In particular, we are interested in a group of proteins called myosin motors which are present in the nucleus and participate in genome organisation, transcription and DNA repair. We investigate how these proteins apply their ability to both transport and anchor multi-protein complexes during DNA processing.

We take a multidisciplinary approach drawing upon core techniques in Cell Biology, Biochemistry, Biophysics, Mechanobiology, Super Resolution imaging and Genomics to reveal the molecular details. In this manner, it is possible to identify both what are the functions and how they function.